| Identification | Back Directory | [Name]
Uridine 5′-(tetrahydrogen triphosphate), 4-thio-, tetralithium salt | [CAS]
20188-72-1 | [Synonyms]
4-Thiouridine 5′-triphosphate tetralithium
Uridine 5′-(tetrahydrogen triphosphate), 4-thio-, tetralithium salt | [Molecular Formula]
C9H15N2O14P3S.4Li | [Molecular Weight]
527.97 |
| Hazard Information | Back Directory | [Uses]
4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetralithium is a potent P2Y2 and P2Y4 receptor agonist, with EC50s of 35 and 350 nM for hP2Y2 and hP2Y4, respectively. 4-Thiouridine 5′-triphosphate tetralithium can be used in the study of crosslinking experiments, labeling of transcriptional complex[1][2]. | [IC 50]
P2Y2 Receptor: 35 nM (EC50); P2Y4 Receptor: 350 nM (EC50) | [References]
[1] Jacobson KA, et, al. Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. Biochem Pharmacol. 2006 Feb 14;71(4):540-9. DOI:10.1016/j.bcp.2005.11.010
[2] Bartholomew B, et, al. RNA contacts subunits IIo and IIc in HeLa RNA polymerase II transcription complexes. J Biol Chem. 1986 Oct 25;261(30):14226-31. PMID:2429953 |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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