| Identification | Back Directory | [Name]
2-AMINO-4-FLUOROBENZOTHIAZOLE | [CAS]
20358-06-9 | [Synonyms]
4-fluorobenzothiazol-2-amine
2-Amino-4-flourobenzothiazol
2-AMINO-4-FLUOROBENZOTHIAZOLE
2-Benzothiazolamine, 4-fluoro-
4-Fluorobenzo[d]thiazol-2-amine
2-Amino-4-fluorobenzo[d]thiazole
4-Fluoro-1,3-benzothiazol-2-amine
2-Benzothiazolamine,4-fluoro-(9CI)
4-Fluoro-benzo[b]thiophen-2-ylamine
4-fluoro-1,3-benzothiazol-2-amine(SALTDATA: FREE) | [Molecular Formula]
C7H5FN2S | [MDL Number]
MFCD04448824 | [MOL File]
20358-06-9.mol | [Molecular Weight]
168.19 |
| Chemical Properties | Back Directory | [Boiling point ]
101 °C | [density ]
1.491±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
2.47±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Synthesis]
General procedure for the synthesis of 2-amino-4-fluorobenzothiazole from 1-(2-fluorophenyl)-2-thiourea: A solution of bromine (0.51 mL, 10.0 mmol) was added slowly and dropwise to a suspension of 1-(2-fluorophenyl)-2-thiourea (1.7 g, 10.0 mmol) in chloroform (25 mL) at room temperature. The reaction mixture was heated to reflux for 3 hours. Upon completion of the reaction, the solvent was removed by evaporation and water was added to the residue and neutralized with ammonium hydroxide solution. The resulting white precipitate was collected by filtration and dried to give 1.2 g (72% yield) of 2-amino-4-fluorobenzothiazole, which could be used in subsequent reactions without further purification. | [References]
[1] Patent: WO2004/11460, 2004, A2. Location in patent: Page 57
[2] Synthetic Communications, 1987, vol. 17, # 2, p. 229 - 240
[3] Journal of the Chemical Society [Section] C: Organic, 1969, p. 268 - 272 |
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