| Identification | Back Directory | [Name]
Benzeneacetamide, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-[[4-[(cyclohexylmethyl)amino]-6-[[(4-fluorophenyl)methyl]amino]-1,3,5-triazin-2-yl]amino]-, hydrochloride (1:1) | [CAS]
2070014-95-6 | [Synonyms]
Benzeneacetamide, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-[[4-[(cyclohexylmethyl)amino]-6-[[(4-fluorophenyl)methyl]amino]-1,3,5-triazin-2-yl]amino]-, hydrochloride (1:1) | [Molecular Formula]
C31H44ClFN8O3 | [MOL File]
2070014-95-6.mol | [Molecular Weight]
631.19 |
| Hazard Information | Back Directory | [Uses]
AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue enolase inhibitor with an IC50 of 0.576 uM. AP-III-a4 hydrochloride can be used for the research of cancer and diabetic[1]. | [in vivo]
AP-III-a4 (ENOblock) (10 μM; 96 h) inhibits cancer cell metastasis and suppresses the gluconeogenesis regulator PEPCK in zebrafish[1]. | Animal Model: | The zebrafish cancer cell HCT116 xenograft model[1] | | Dosage: | 10 μM | | Administration: | 96 h | | Result: | Reduced cancer cell dissemination. Inhibited PEPCK expression and induced glucose uptake. Inhibited adipogenesis and foam cell formation. |
| [References]
[1] Da-Woon Jung, et al. A Unique Small Molecule Inhibitor of Enolase Clarifies Its Role in Fundamental Biological Processes.ACS Chem. Biol., 2013, 8 (6), pp 1271–1282 DOI:10.1021/cb300687k |
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