| Identification | Back Directory | [Name]
Decanoic acid, 2-octyl-, 7-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]heptyl ester | [CAS]
2089251-57-8 | [Synonyms]
7-[(2-Hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]heptyl 2-octyldecanoate
Decanoic acid, 2-octyl-, 7-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]heptyl ester | [Molecular Formula]
C44H87NO5 | [MOL File]
2089251-57-8.mol | [Molecular Weight]
710.17 |
| Chemical Properties | Back Directory | [Boiling point ]
726.2±50.0 °C(Predicted) | [density ]
0.925±0.06 g/cm3(Predicted) | [solubility ]
Chloroform: Slightly Soluble: 0.1-1 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml
Methanol: Sparingly Soluble: 1-10 mg/ml | [pka]
14.67±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Lipid-M, also known as 7-[(2-Hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]heptyl 2-octyldecanoate, analog of ALC-0315, is a ionizable, physiological pH cationic synthetic lipid that is used with other lipids to form lipid nanoparticles(LNP) for drug delivery. | [Uses]
Lipid M (pKa: 6.75) can be used to deliver mRNA vaccine and yield a robust immune response with improved tolerability[1]. | [in vivo]
Lipid M (50 μL containing 2 μg of luciferase mRNA formulated in LNPs, i.m.) is followed by rapid clearance in muscle, spleen and liver in CD-1 mice[1].
Lipid M (300 μL containing 500 μg IgG mRNA formulated in LNPs, i.m.) yields serum antibody expression comparable to that of MC3-based LNPs in cynomolgus monkeys[1].
| [References]
[1] Hassett KJ, et al. Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines. Mol Ther Nucleic Acids. 2019 Apr 15;15:1-11. DOI:10.1016/j.omtn.2019.01.013 |
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