| Hazard Information | Back Directory | [Uses]
PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1?/?) and Capan-1 (BRCA2?/?) cells with IC50 values below 0.3 nM[1]. | [IC 50]
PARP1: 0.6 ± 0.1 nM (IC50) | [References]
[1] Wang P, et al. Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities. Eur J Med Chem. 2023 Nov 5;259:115709. DOI:10.1016/j.ejmech.2023.115709 |
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