ChemicalBook--->CAS DataBase List--->2170606-94-5

2170606-94-5

2170606-94-5 Structure

2170606-94-5 Structure
IdentificationBack Directory
[Name]

MAK-683 hyrochloride
[CAS]

2170606-94-5
[Synonyms]

MAK-683 hyrochloride
MAK-683 hydrochloride
EED inhibitor,MAK 683 hyrochloride,embryonic ectoderm development,Histone Methyltransferase,MAK 683,inhibit,MAK-683,MAK683,MAK683 hyrochloride,Inhibitor
[Molecular Formula]

C20H18ClFN6O
[MOL File]

2170606-94-5.mol
[Molecular Weight]

412.85
Hazard InformationBack Directory
[Uses]

MAK683 hydrochloride is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2. MAK683 exhibits IC50s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay[1][2].
[References]

[1] Chan, Ho Man, et al. TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF. US20160176882 A1.
[2] Huang D, et al. Binding Modes of Small-Molecule Inhibitors to the EED Pocket of PRC2. Chemphyschem. 2020 Feb 4;21(3):263-271. DOI:10.1002/cphc.201900903
Spectrum DetailBack Directory
[Spectrum Detail]

MAK-683 hyrochloride(2170606-94-5)1HNMR
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