ChemicalBook--->CAS DataBase List--->217658-18-9

217658-18-9

217658-18-9 Structure

217658-18-9 Structure
IdentificationBack Directory
[Name]

Z-ALA-PRO-PHE-CHLOROMETHYLKETONE
[CAS]

217658-18-9
[Synonyms]

Z-ALA-PRO-PHE-CMK
Z-ALA-PRO-PHE-CHLOROMETHYLKETONE
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]- (9CI)
[Molecular Formula]

C26H30ClN3O5
[MDL Number]

MFCD00238409
[MOL File]

217658-18-9.mol
[Molecular Weight]

499.99
Chemical PropertiesBack Directory
[storage temp. ]

-15°C
[Sequence]

Z-Ala-Pro-Phe-{Chloromethylketone}
Hazard InformationBack Directory
[Uses]

Z-APF-CMK is a specific inhibitor of Ca2+-regulated nuclear scaffold protease (CRNSP)[1].
[References]

[1] Zhang D, et al. Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5746-51. DOI:10.1073/pnas.101329598
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