| Identification | Back Directory | [Name]
2-oxa-6-azaspiro[3.4]octane | [CAS]
220290-68-6 | [Synonyms]
2-oxa-6-azaspiro[3.4]octane
2-oxa-7-azaspiro[3.4]octane
2-Oxa-6-azaspiro[3.4]octa...
2-Oxa-6-azaspiro[3.4]octane,95%
2-oxa-6-azaspiro[3.4]octane, hemioxalate salt | [Molecular Formula]
C6H11NO | [MDL Number]
MFCD14586455 | [MOL File]
220290-68-6.mol | [Molecular Weight]
113.158 |
| Chemical Properties | Back Directory | [Boiling point ]
187℃ | [density ]
1.08 | [Fp ]
63°(145°F) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [pka]
10.55±0.20(Predicted) | [Water Solubility ]
Soluble in water. | [InChI]
InChI=1S/C6H11NO/c1-2-7-3-6(1)4-8-5-6/h7H,1-5H2 | [InChIKey]
ZHAIMJRKJKQNQI-UHFFFAOYSA-N | [SMILES]
C1C2(CCNC2)CO1 |
| Hazard Information | Back Directory | [Uses]
2-Oxa-6-azaspiro[3.4]octane is involved in the preparation of azaspirocycle or azetidine substituted 4-anilinoquinazoline derivatives, which exhibits epidermal growth factor receptor (EGFR) inhibitory activities. | [Application]
2-Oxa-6-Azaspiro[3.4]Octane Hydrochloride may be useful in the preparation of aminocyanopyridine derivatives for the prevention or treatment of cancer or inflammatory diseases. | [Synthesis]
Tert-butyl 2-oxa-6-azaspiro[3.4]octane-6-carboxylate (86mg, 0.4mmol) was dissolved in dichloromethane (1mL), trifluoroacetic acid (2mL) was added to the system at room temperature, and the reaction solution was heated at 60°C for 2h. The reaction solution was cooled to room temperature and concentrated under reduced pressure to obtain crude product 2-oxa-6-azaspiro[3.4]octane.
![2-oxa-6-azaspiro[3.4]octane](/NewsImg/2023-10-20/6383340614380040227619222.jpg "2-oxa-6-azaspiro[3.4]octane") |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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