| Identification | Back Directory | [Name]
PKCiota-IN-51 | [CAS]
2230052-97-6 | [Synonyms]
PKCiota-IN-1
PKCiota-IN-51
Isoquinoline, 3-(fluoromethyl)-1,2,3,4-tetrahydro-6-methoxy-7-[5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl]- | [Molecular Formula]
C25H22FN5O | [MOL File]
2230052-97-6.mol | [Molecular Weight]
427.47 |
| Hazard Information | Back Directory | [Uses]
PKCiota-IN-1 (compound 51) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.7 nM. PKCiota-IN-1 also inhibits PKC-α and PKC-ε with IC50s of 45 nM and 450 nM, respectively[1]. | [IC 50]
PKCι: 2.7 nM (IC50); PKCα: 45 nM (IC50); PKCε: 450 nM (IC50) | [References]
[1] Jacek Kwiatkowski, et al. Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors. J Med Chem. 2018 May 24;61(10):4386-4396. DOI:10.1021/acs.jmedchem.8b00060 |
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