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2230145-14-7

2230145-14-7 Structure

2230145-14-7 Structure
IdentificationBack Directory
[Name]

XPC-5462
[CAS]

2230145-14-7
[Synonyms]

XPC-5462
Hazard InformationBack Directory
[Uses]

XPC-5462 is a NaV1.6 and NaV1.2 inhibitor with the IC50s of 10.9 nM and 10.3 nM, respectively. XPC-5462 suppresses epileptiform activity in an ex vivo brain slice seizure model[1].
[IC 50]

Nav1.2: 10.3 nM (IC50); Nav1.6: 10.9 nM (IC50)
[References]

[1] Goodchild SJ,et al. Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo. ACS Chem Neurosci. 2024 Feb 15. DOI:10.1021/acschemneuro.3c00757
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