ChemicalBook--->CAS DataBase List--->2231075-94-6

2231075-94-6

2231075-94-6 Structure

2231075-94-6 Structure
IdentificationBack Directory
[Name]

BI-1408
[CAS]

2231075-94-6
[Synonyms]

BI-1408
BI1408,BI 1408
[1,2,4]Triazolo[1,5-a]pyridin-2-amine, N-[(5R)-1-ethyl-4,5,6,7-tetrahydro-1H-indazol-5-yl]-8-(4-fluoro-2-methylphenyl)-
[Molecular Formula]

C22H23FN6
[MDL Number]

MFCD31813662
[MOL File]

2231075-94-6.mol
[Molecular Weight]

390.46
Chemical PropertiesBack Directory
[density ]

1.36±0.1 g/cm3(Predicted)
[pka]

4.14±0.30(Predicted)
Hazard InformationBack Directory
[Uses]

BI-1408 is a potent γ secretase modulator with an IC50 of 0.04 μM for Aβ42[1].
[References]

[1] Gerlach K, et al. Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators. Bioorg Med Chem. 2018 Jul 23;26(12):3227-3241. DOI:10.1016/j.bmc.2018.04.053
Spectrum DetailBack Directory
[Spectrum Detail]

BI-1408(2231075-94-6)1HNMR
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2231075-94-6