ChemicalBook--->CAS DataBase List--->2260631-91-0

2260631-91-0

2260631-91-0 Structure

2260631-91-0 Structure
IdentificationBack Directory
[Name]

1H-Indole-5-carboxamide, 2-[[4-chloro-2-(trifluoromethyl)phenyl]methyl]-N-[(1R)-1-[4-(ethylsulfonyl)phenyl]-2-hydroxyethyl]-1-(2-fluoroethyl)-
[CAS]

2260631-91-0
[Synonyms]

1H-Indole-5-carboxamide, 2-[[4-chloro-2-(trifluoromethyl)phenyl]methyl]-N-[(1R)-1-[4-(ethylsulfonyl)phenyl]-2-hydroxyethyl]-1-(2-fluoroethyl)-
[Molecular Formula]

C29H27ClF4N2O4S
[MOL File]

2260631-91-0.mol
[Molecular Weight]

611.05
Chemical PropertiesBack Directory
[Boiling point ]

790.8±60.0 °C(Predicted)
[density ]

1.38±0.1 g/cm3(Predicted)
[pka]

13.04±0.46(Predicted)
Hazard InformationBack Directory
[Uses]

RORγ agonist 1 is a potent and orally bioavailable RORγ agonist (EC50 = 21 nM) with antitumor activity.
[References]

[1] Lu B, et al. Discovery of 2-(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity. J Med Chem. 2021 Oct 28;64(20):14983-14996. DOI:10.1021/acs.jmedchem.1c00828
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