一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
+1 (818) 612-2111
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >Biochemical Engineering>Plant extracts>Plant Extracts>Euphol
Euphol
  • Euphol

Euphol NEW

Price $84 $198 $347
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-24

Product Details

Product Name: Euphol CAS No.: 514-47-6
Purity: 99.85% Supply Ability: 10g
Release date: 2026/05/24

Product Introduction

Bioactivity

NameEuphol
DescriptionEuphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.
Animal ResearchFor the induction of inflammatory pain, mice received an intraplantar injection of 20 ml of carrageenan (300 ug/paw) under the surface of the right hindpaw.?To assess the systemic effect of drug treatment, mice received euphol (3, 30 or 100 ug/kg) or its vehicle (5% Tween 80 solution made in saline e 0.9% NaCl solution), 1 h before carrageenan injection.?Other group of mice received dexamethasone (0.5 mg/kg.) 1 h before carrageenan?injection that was used as positive control drug.?The development of mechanical hyperalgesia was evaluated at 1, 2, 4, 6, 8, 24 and 48 h time points, after drug pre-treatments.?In order to evaluate the possible site of action of euphol (central or peripheral), a separate group of animals received an i.pl.?injection of euphol (5, 10 or 30 ug/paw) 15 min prior carrageenan (300 ug/paw) administration.?Additional groups of animals received an intrathecal (1, 3 and 10 ug/site) or intracerebroventricular ?(0.3, 3 or 10 ug/site) injection of 5 ml of euphol, 15 min before the paw injection of carrageenan.?Compared the analgesic efficacy of euphol with different groups of standard analgesic drugs, as described previously: indomethacin (2 mg/kg), morphine (5 mg/kg.), gabapentin (70 mg/kg) and dipyrone (120 mg/kg).?All drugs were administered 1 h before i.pl.?carrageenan injection (300 ug/paw).?Mechanical hyperalgesia was evaluated at 1, 2, 4, 6, 8 and 24 h time points after carrageenan injection, and measured with VFH.
In vivoOral treatment with euphol (30 and 100 mg/kg) reduced carrageenan-induced mechanical hyperalgesia. Likewise, euphol given through the spinal and intracerebroventricular routes prevented mechanical hyperalgesia induced by carrageenan. Euphol consistently blocked the mechanical hyperalgesia induced by complete Freund's adjuvant, keratinocyte-derived chemokine, interleukin-1β, interleukin-6 and tumor necrosis factor-alpha associated with the suppression of myeloperoxidase activity in the mouse paw. Oral treatment with euphol was also effective in preventing the mechanical nociceptive response induced by ligation of the sciatic nerve and also significantly reduced the levels and mRNA of cytokines/chemokines in both paw and spinal cord tissues following i.pl. injection of complete Freund's adjuvant. In addition, the pre-treatment with either CB?R or CB?R antagonists, as well as the knockdown gene of the CB?R and CB?R, significantly reversed the antinociceptive effect of euphol.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 4.27 mg/mL (10.01 mM), Sonication is recommended.
KeywordsMonoacylglycerol lipase | MAGL | Inhibitor | inhibit | euphol | EndogenousMetabolite | Endogenous Metabolite
Inhibitors RelatedSucrose | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Guanidine thiocyanate | Malic acid | Glycerol | Thymidine | Corn starch | Gluconate Calcium | DL-Lysine
Related Compound LibrariesTerpene Natural Product Library | Traditional Chinese Medicine Monomer Library | Pain-Related Compound Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | NO PAINS Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
Shanghai Standard Technology Co., Ltd.
2020-01-21
$9.80
VIP7Y
Career Henan Chemical Co
2020-01-10

TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY
新昌县| 汕头市| 宝兴县| 渑池县| 稻城县| 增城市| 启东市| 乾安县| 乾安县| 崇州市| 大新县| 大港区| 垫江县| 阿坝| 桦南县| 黄平县| 克山县| 大渡口区| 赤壁市| 方正县| 枣强县| 正蓝旗| 黑河市| 平阳县| 内黄县| 惠来县| 崇左市| 临洮县| 普安县| 雷波县| 宜黄县| 浏阳市| 武邑县| 水富县| 大英县| 四会市| 赤峰市| 巴林左旗| 新宾| 民丰县| 四平市|