| Identification | Back Directory | [Name]
Benzonitrile, 4-[[2-[(2-furanylmethyl)amino]-1H-benzimidazol-1-yl]methyl]- | [CAS]
2265215-18-5 | [Synonyms]
TRPC5-IN-1
Benzonitrile, 4-[[2-[(2-furanylmethyl)amino]-1H-benzimidazol-1-yl]methyl]-
4-((2-((Furan-2-ylmethyl)amino)-1H-benzo[d]imidazol-1-yl)methyl)benzonitrile | [Molecular Formula]
C20H16N4O | [MOL File]
2265215-18-5.mol | [Molecular Weight]
328.37 |
| Chemical Properties | Back Directory | [Boiling point ]
577.3±60.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
5.72±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TRPC5-IN-1 (Compound 6j) is a selective TRPC5 inhibitor with 50.5 % Inhibition for TRPC5 at 3 μM. TRPC5-IN-1 can be used for the research of chronic kidney disease (CKD)[1]. | [References]
[1] Sharma SH, et al. Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903. Bioorg Med Chem Lett. 2019 Jan 15;29(2): DOI:10.1016/j.bmcl.2018.12.007 |
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