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2278141-79-8

2278141-79-8 Structure

2278141-79-8 Structure
IdentificationBack Directory
[Name]

Ethanesulfonic acid, 2-[[(3α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)
[CAS]

2278141-79-8
[Synonyms]

Tauro-Obeticholic Acid sodium
Tauro-Obeticholic Acid (sodium salt)
Ethanesulfonic acid, 2-[[(3α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)
[Molecular Formula]

C28H50NNaO6S
[MOL File]

2278141-79-8.mol
[Molecular Weight]

551.76
Chemical PropertiesBack Directory
[solubility ]

DMF: 20 mg/ml
DMSO: 20 mg/ml
Ethanol: 20 mg/mlPBS (pH 7.2): 2 mg/ml
Hazard InformationBack Directory
[Uses]

Tauro-obeticholic acid sodium is an active metabolite of Obeticholic acid (HY-12222). Obeticholic acid is a potent, selective and orally active FXR agonist.
[References]

[1] Xiaojiao Li, et al. Comparison of the Pharmacokinetics of Generic Versus Branded Obeticholic Acid in a Chinese Population: Effects of Food and Sex. Clin Pharmacol Drug Dev. 2021 Jul;10(7):797-806. DOI:10.1002/cpdd.905
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