| Identification | Back Directory | [Name]
2H-Benzimidazol-2-one, 1-[1-[[5-[(2E)-3-(2,4-dichlorophenyl)-1-oxo-2-propen-1-yl]-2-ethoxy-4-hydroxyphenyl]methyl]-1,2,5,6-tetrahydro-3-pyridinyl]-1,3-dihydro- | [CAS]
2296718-09-5 | [Synonyms]
2H-Benzimidazol-2-one, 1-[1-[[5-[(2E)-3-(2,4-dichlorophenyl)-1-oxo-2-propen-1-yl]-2-ethoxy-4-hydroxyphenyl]methyl]-1,2,5,6-tetrahydro-3-pyridinyl]-1,3-dihydro- | [Molecular Formula]
C30H27Cl2N3O4 | [MOL File]
2296718-09-5.mol | [Molecular Weight]
564.46 |
| Hazard Information | Back Directory | [Uses]
SHP2 inhibitor LY6 (LY6) is potent and selective inhibitor of SHP2, with an IC50 of 9.8 μM. SHP2 inhibitor LY6 can inhibits SHP2-mediated cell signaling and proliferation[1]. | [References]
[1] Wu X, et, al. Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2. J Med Chem. 2019 Feb 14;62(3):1125-1137. DOI:10.1021/acs.jmedchem.8b00513 |
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