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2300967-40-0

2300967-40-0 Structure

2300967-40-0 Structure
IdentificationBack Directory
[Name]

4-(4-acryloyl-3,5-dimethylpiperazin-1-yl)-7-(2-amino-6-fluorophenyl)-6-chloro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one
[CAS]

2300967-40-0
[Synonyms]

KRAS G12C inhibitor 61
[Molecular Formula]

C31H33ClFN7O2
[MOL File]

2300967-40-0.mol
[Molecular Weight]

590.091
Chemical PropertiesBack Directory
[Boiling point ]

752.3±70.0 °C(Predicted)
[density ]

1.36±0.1 g/cm3(Predicted)
[pka]

6.17±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

KRAS G12C inhibitor 61 (Example 3) inhibits phospho-ERK 1/2 in MIA PaCa-2 cells with an IC50 value of 9 nM. KRAS G12C inhibitor 61 can be used for research of pancreatic, colorectal, and lung cancers[1].
[IC 50]

K-Ras WT
[References]

[1] Brian Alan Lanman, et al. Inhibitors of kras g12c and methods of using the same. Patent. WO2019051291.
2300967-40-0 suppliers list
Company Name: TargetMol Chemicals Inc.
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Company Name: Nantong Hanfang Biotechnology Co. , Ltd.  
Tel: hanfangpharma@126.com 18017580634
Website: hanfangpharma@126.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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