| Identification | Back Directory | [Name]
Butanoic acid, 4-[[[(2S)-1-(benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]- | [CAS]
2326220-69-1 | [Synonyms]
(S)-GLPG0974
Butanoic acid, 4-[[[(2S)-1-(benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]- | [Molecular Formula]
C25H25ClN2O4S | [MOL File]
2326220-69-1.mol | [Molecular Weight]
484.99 |
| Chemical Properties | Back Directory | [Boiling point ]
726.3±60.0 °C(Predicted) | [density ]
1.374±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.63±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(S)-GLPG0974 is the isomer of GLPG0974 (HY-12940), and can be used as an experimental control. GLPG0974 is a free fatty acid receptor-2 (FFA2/GPR43) antagonist with an IC50 of 9 nM. | [References]
[1] Pizzonero M, et al. Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J Med Chem. 2014 Dec 11;57(23):10044-57. DOI:10.1021/jm5012885 |
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