| Identification | Back Directory | [Name]
Cholest-5-en-26-oic-27,27,27-d3 acid, 3-hydroxy-7-oxo-, (3β)- | [CAS]
2342573-92-4 | [Synonyms]
Cholest-5-en-26-oic-27,27,27-d3 acid, 3-hydroxy-7-oxo-, (3β)- | [Molecular Formula]
C27H42O4 | [MOL File]
2342573-92-4.mol | [Molecular Weight]
430.63 |
| Hazard Information | Back Directory | [Description]
3β-hydroxy-7-oxo-5-Cholestenoic Acid-d3 is intended for use as an internal standard for the quantification of 3β-hydroxy-7-oxo-5-cholestenoic acid by GC- or LC-MS. 3β-hydroxy-7-oxo-5-Cholestenoic acid is a metabolite of the oxysterol 7-keto cholesterol .1 It is formed from 7-keto cholesterol by the cytochrome P450 (CYP) isoform CYP27A1. Plasma levels of 3β-hydroxy-7-oxo-5-cholestenoic acid are increased in a rat model of liver injury induced by carbon tetrachloride.2 | [Uses]
3β-Hydroxy-7-oxocholest-5-enoic acid-d3 is deuterium labeled 3β-Hydroxy-7-oxocholest-5-enoic acid. | [References]
1. Heo, G.-Y., Bederman, I., Mast, N., et al. Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells J. Lipid Res. 52(6),1117-1127(2011).
2. Xu, S.-Y., Zhang, Y., Han, T., et al. Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry-based plasma metabolomics study of hepatoprotective effect of cuscutae semen on CCl4 -induced liver injury model of rats Biomed. Chromatogr. 36(12),e5489(2022). |
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Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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