| Identification | Back Directory | [Name]
Benzenemethanamine, 3-[[4-(2,3-dihydro-1,4-benzodioxin-5-yl)-2-methoxyphenyl]amino]-N,N-dimethyl- | [CAS]
2368246-78-8 | [Synonyms]
Compound 3344
Benzenemethanamine, 3-[[4-(2,3-dihydro-1,4-benzodioxin-5-yl)-2-methoxyphenyl]amino]-N,N-dimethyl- | [Molecular Formula]
C24H26N2O3 | [MOL File]
2368246-78-8.mol | [Molecular Weight]
390.47 |
| Hazard Information | Back Directory | [Uses]
pan-KRAS-IN-16 (Compound 3344) is an anti-RAS small molecule derived from an intracellular antibody fragment with pan-RAS-effector protein-protein interaction inhibitor properties. pan-KRAS-IN-16 binds to a hydrophobic pocket near to the effector-binding switch regions of RAS. pan-KRAS-IN-16 prevents endogenous RAS-dependent signaling in tumor cell lines[1]. | [IC 50]
KRas G12D; H-Ras; Ras | [References]
[1] Bery N, et al. BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions. Elife. 2018 Jul 10;7:e37122. DOI:10.7554/eLife.37122 |
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