| Identification | Back Directory | [Name]
TRPA1-IN-1 | [CAS]
2376824-92-7 | [Synonyms]
TRPA1-IN-1
1-[[3-[(3R,5R)-5-(4-chlorophenyl)oxolan-3-yl]-1,2,4-oxadiazol-5-yl]methyl]-7-methylpurin-6-one
6H-Purin-6-one, 1-[[3-[(3R,5R)-5-(4-chlorophenyl)tetrahydro-3-furanyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl- | [Molecular Formula]
C19H17ClN6O3 | [MOL File]
2376824-92-7.mol | [Molecular Weight]
412.83 |
| Hazard Information | Back Directory | [Uses]
TRPA1-IN-1 is a potent, selective, and orally bioavailable TRPA1 small molecule antagonist. | [References]
[1] Terrett JA, et al. Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy. J Med Chem. 2021 Apr 8;64(7):3843-38 DOI:10.1021/acs.jmedchem.0c02023 |
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