| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2382768-55-8 | [Synonyms]
| [Molecular Formula]
C93H134N10O24 | [Molecular Weight]
1776.11 |
| Chemical Properties | Back Directory | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture | [solubility ]
DMSO : 146.67 mg/mL (82.58 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.40±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2)[1]. | [Biological Activity]
(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2)[1]. | [storage]
4°C, away from moisture | [References]
[1]. Jennifer PITZEN, et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1. |
|
|