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2406276-78-4

2406276-78-4 Structure

2406276-78-4 Structure
IdentificationBack Directory
[Name]

OM-1700
[CAS]

2406276-78-4
[Synonyms]

OM-1700
2-Pyridinecarboxamide, N-[trans-3-[5-(5-ethoxy-2-pyridinyl)-4-(2-fluorophenyl)-4H-1,2,4-triazol-3-yl]cyclobutyl]-
[Molecular Formula]

C25H23FN6O2
[MOL File]

2406276-78-4.mol
[Molecular Weight]

458.49
Chemical PropertiesBack Directory
[density ]

1.38±0.1 g/cm3(Predicted)
[pka]

12.81±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

OM-1700 is a potent tankyrase inhibitor with IC50s of 127 and 14 nM for tankyrase 1 and tankyrase 2, respectively. OM-1700 reduces cell growth in the colon cancer cell line COLO 320DM (GI50=650 nM)[1].
[IC 50]

TNKS1: 127 nM (IC50); TNKS2: 14 nM (IC50)
[References]

[1] Leenders RGG, et al. Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J Med Chem. 2021;64(24):17936-17949. DOI:10.1021/acs.jmedchem.1c01264
2406276-78-4 suppliers list
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Company Name: Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd  
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Company Name: TargetMol Chemicals Inc.  
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Website: https://www.targetmol.cn/
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