| Identification | Back Directory | [Name]
1-Piperazineoctanamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-4-[6-[[2-[(4-fluorophenyl)amino]-4-[4-(hydroxymethyl)-1-piperidinyl]pyrido[3,4-d]pyrimidin-6-yl]amino]-3-pyridinyl]- | [CAS]
2409793-28-6 | [Synonyms]
1-Piperazineoctanamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-4-[6-[[2-[(4-fluorophenyl)amino]-4-[4-(hydroxymethyl)-1-piperidinyl]pyrido[3,4-d]pyrimidin-6-yl]amino]-3-pyridinyl]- | [Molecular Formula]
C49H57FN12O5 | [MOL File]
2409793-28-6.mol | [Molecular Weight]
913.05 |
| Hazard Information | Back Directory | [Uses]
PROTAC EGFR degrader 6, a PROTAC EGFR degrader, potently degrades EGFRDel19 in HCC827 cells with the DC50 of 45.2 nM. PROTAC EGFR degrader 6 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase[1]. | [References]
[1] Hao Zhang, et al. Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC). Eur J Med Chem. 2020 Mar 1;189:112061. DOI:10.1016/j.ejmech.2020.112061 |
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