| Identification | Back Directory | [Name]
(11b)-11,17,21-trihydroxy-3,20-dioxo-Pregn-4-en-18-al | [CAS]
2410-60-8 | [Synonyms]
18-Oxocortisol
(11b)-11,17,21-trihydroxy-3,20-dioxo-Pregn-4-en-18-al
Pregn-4-en-18-al, 11,17,21-trihydroxy-3,20-dioxo-, (11β)- | [Molecular Formula]
C21H28O6 | [MDL Number]
MFCD29920152 | [MOL File]
2410-60-8.mol | [Molecular Weight]
376.44 |
| Chemical Properties | Back Directory | [Melting point ]
208.5-209.5 °C | [Boiling point ]
606.4±55.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) | [form ]
Solid | [pka]
11.85±0.70(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
18-Oxocortisol is used in biological studies on anti-malarial drug artesunate restoring metabolic changes in experimental allergic astham. | [in vivo]
Administration of 18-oxocortisol to rats induces a mineralocorticoid-type hypertension with hypokalemia, cardiac and renal enlargement and cardiovascular lesions. Administration of 18-oxocortisol to sheep also causes a rapid increase in blood pressure. However, the doses required for increasing blood pressure are high[3]. |
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