| Identification | Back Directory | [Name]
[[(12aR)-12-[(10S)-6,7-Difluoro-5,10-dihydrothieno[3,2-c][2]benzothiepin-10-yl]-3,4,6,8,12,12a-hexahydro-6,8-dioxo-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl]oxy]methyl methyl carbonate | [CAS]
2417851-93-3 | [Synonyms]
[[(12aR)-12-[(10S)-6,7-Difluoro-5,10-dihydrothieno[3,2-c][2]benzothiepin-10-yl]-3,4,6,8,12,12a-hexahydro-6,8-dioxo-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl]oxy]methyl methyl carbonate | [Molecular Formula]
C25H21F2N3O7S2 | [MOL File]
2417851-93-3.mol | [Molecular Weight]
577.58 |
| Chemical Properties | Back Directory | [Boiling point ]
720.8±70.0 °C(Predicted) | [density ]
1.63±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
-1.47±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AV5124, a prodrug of AV5116, is an orally active influenza virus cap-dependent endonuclease (CEN) endonuclease inhibitor[1]. | [in vivo]
AV5124 at a dose of 20 mg/kg prevented death in 60% of animals, and at 50 mg/kg it completely protected mice from virus-caused death[1]. | [References]
[1] Andrei A Ivashchenko, et al. Synthesis, inhibitory activity and oral dosing formulation of AV5124, the structural analogue of influenza virus endonuclease inhibitor baloxavir. J Antimicrob Chemother. 2021 Mar 12;76(4):1010-1018. DOI:10.1093/jac/dkaa524 |
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