| Identification | Back Directory | [Name]
Benzonitrile, 2-[[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]methyl]-4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)- | [CAS]
2425804-98-2 | [Synonyms]
HCV-IN-37
Benzonitrile, 2-[[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]methyl]-4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)- | [Molecular Formula]
C31H35F2N5 | [MOL File]
2425804-98-2.mol | [Molecular Weight]
515.64 |
| Hazard Information | Back Directory | [Uses]
HCV-IN-37 (Compound 3d) is a potent inhibitor of HCV. HCV-IN-37 is orally available and long-lasting in rat plasma after oral administration to rats by a single dose of 15 mg/kg. The high potency of active derivative HCV-IN-37 is primarily driven by the inhibitory effect on the virus entry stage[1]. | [References]
[1] Wang Y, et al. Design, Synthesis, and Biological Evaluation of 2-((4-Bisarylmethyl-piperazin-1-yl)methyl)benzonitrile Derivatives as HCV Entry Inhibitors. J Med Chem. 2022 Feb 10;65(3):2107-2121. DOI:10.1021/acs.jmedchem.1c01637 |
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