| Identification | Back Directory | [Name]
Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- | [CAS]
2444364-04-7 | [Synonyms]
EGFR/HER2/TS-IN-2
Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)- | [Molecular Formula]
C26H21N7OS2 | [MOL File]
2444364-04-7.mol | [Molecular Weight]
511.62 |
| Hazard Information | Back Directory | [Uses]
EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 μM[1]. | [IC 50]
HER2: 0.125 ± 0. μM (IC50); EGFR: 0.173 ± 0. μM (IC50) | [References]
[1] Abdellatif KRA, et al. Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Bioorg Chem. 2020 Aug;101:103976. DOI:10.1016/j.bioorg.2020.103976 |
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