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2446055-29-2

2446055-29-2 Structure

2446055-29-2 Structure
IdentificationBack Directory
[Name]

Benzoic acid, 3-[4-[[[3,4-dihydro-6-methyl-4-oxo-3-(phenylmethyl)-2-quinazolinyl]thio]methyl]-1H-1,2,3-triazol-1-yl]-
[CAS]

2446055-29-2
[Synonyms]

HSP90-IN-13
Benzoic acid, 3-[4-[[[3,4-dihydro-6-methyl-4-oxo-3-(phenylmethyl)-2-quinazolinyl]thio]methyl]-1H-1,2,3-triazol-1-yl]-
[Molecular Formula]

C26H21N5O3S
[MOL File]

2446055-29-2.mol
[Molecular Weight]

483.54
Chemical PropertiesBack Directory
[Boiling point ]

768.6±70.0 °C(Predicted)
[density ]

1.38±0.1 g/cm3(Predicted)
[pka]

3.75±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC50 value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway[1].
[IC 50]

HSP90: 25.07 nM (IC50); Topoisomerase-2: 25.85 nM (IC50); EGFR: 38.5 nM (IC50); VEGFR-2: 126.95 nM (IC50)
[References]

[1] El-Shafey HW, et al. Synthetic approaches, anticancer potential, HSP90 inhibition, multitarget evaluation, molecular modeling and apoptosis mechanistic study of thioquinazolinone skeleton: Promising antibreast cancer agent. Bioorg Chem. 2020 Aug;101:10398 DOI:10.1016/j.bioorg.2020.103987
2446055-29-2 suppliers list
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