| Identification | Back Directory | [Name]
Benzonitrile, 3-[[4-chloro-5-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]-2-[[2-(1-piperazinylcarbonyl)-1-piperidinyl]methyl]phenoxy]methyl]- | [CAS]
2447066-14-8 | [Synonyms]
Benzonitrile, 3-[[4-chloro-5-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]-2-[[2-(1-piperazinylcarbonyl)-1-piperidinyl]methyl]phenoxy]methyl]- | [Molecular Formula]
C41H43ClN4O5 | [MOL File]
2447066-14-8.mol | [Molecular Weight]
707.26 |
| Hazard Information | Back Directory | [Uses]
BMS-1166-N-piperidine-CO-N-piperazine incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1]. | [References]
[1] Cheng B, Ren Y, Cao H, Chen J. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377. DOI:10.1016/j.ejmech.2020.112377 |
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