| Identification | Back Directory | [Name]
Benzamide, 3-[[(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)amino]sulfonyl]-N-hydroxy-4-methoxy- | [CAS]
2484255-85-6 | [Synonyms]
HDAC8/BRPF1-IN-1
Benzamide, 3-[[(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)amino]sulfonyl]-N-hydroxy-4-methoxy- | [Molecular Formula]
C19H19N3O6S | [MOL File]
2484255-85-6.mol | [Molecular Weight]
417.44 |
| Hazard Information | Back Directory | [Uses]
HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and BRPF1 with an IC50 of 443 nM against human HDAC8 and a Kd of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6[1]. | [IC 50]
hHDAC8: 443 nM (IC50); hBRPF1: 67 nM (Ki) | [References]
[1] Ghazy E, et al. Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1. Eur J Med Chem. 2020 Aug 15;200:112338. DOI:10.1016/j.ejmech.2020.112338 |
|
|