| Identification | Back Directory | [Name]
1H-Pyrazole-4-carboxamide, N-[4-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl- | [CAS]
2487649-73-8 | [Synonyms]
Axl-IN-9
1H-Pyrazole-4-carboxamide, N-[4-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl- | [Molecular Formula]
C25H23N7O2 | [MOL File]
2487649-73-8.mol | [Molecular Weight]
453.5 |
| Hazard Information | Back Directory | [Uses]
Axl-IN-9 (Example 10) is a potent AXL inhibitor, with an IC50 of 26 nM. Axl-IN-9 has excellent transmembrane properties. Axl-IN-9 exhibits excellent pharmacokinetic properties in an animal body. Axl-IN-9 can be used for the research of proliferative diseases, autoimmune diseases, allergic diseases, inflammatory diseases, transplant rejection, cancer, or other diseases in mammals[1]. | [IC 50]
Axl | [References]
[1] Xi Ning. Substituted heteroaryl compound, composition of same, and uses thereof. WO2020182188A1. |
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