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2489528-97-2

2489528-97-2 Structure

2489528-97-2 Structure
IdentificationBack Directory
[Name]

FLT3-IN-23
[CAS]

2489528-97-2
[Synonyms]

FLT3-IN-23
[Molecular Formula]

C22H28F3N5O2
[MOL File]

2489528-97-2.mol
[Molecular Weight]

451.49
Chemical PropertiesBack Directory
[Boiling point ]

599.7±60.0 °C(predicted)
[density ]

1.307±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

10.39±0.70(predicted)
Hazard InformationBack Directory
[Uses]

FLT3-IN-23 (compound 15) is an inhibitor of JFMS-like tyrosine kinase 3 (FLT3) with an IC50 of 7.42 nM. FLT3-IN-23 has antiproliferative activities against BaF3 cells carrying various FLT3-TKD and FLT3-ITD-TKD mutations[1].
[References]

[1] Xuanmin Lian, et al. Design, synthesis and biological evaluation of 2-aminopyrimidine derivatives as potent FLT3 inhibitors. Bioorg Med Chem Lett. 2023, 23. DOI:10.1016/j.bmcl.2023.129519
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