| Identification | Back Directory | [Name]
2-Piperazineacetonitrile, 4-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-(4-pentyn-1-yl)-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2S)- | [CAS]
2490716-96-4 | [Synonyms]
MRTX849 analog 24
Azvudine Impurity 32
4-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-(4-pentyn-1-yl)-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-
2-Piperazineacetonitrile, 4-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-(4-pentyn-1-yl)-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2S)- | [Molecular Formula]
C36H39ClFN7O2 | [MDL Number]
MFCD34471173 | [MOL File]
2490716-96-4.mol | [Molecular Weight]
656.19 |
| Chemical Properties | Back Directory | [Boiling point ]
895.1±75.0 °C(Predicted) | [density ]
1.269±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
8.94±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MRTX849 analog 24 is an alkyne-containing click probe analogue of KRAS G12C inhibitor MRTX849, which is used to research MRTX849 function[1]. | [References]
[1] Jay B Fell, et al. Identification of the Clinical Development Candidate MRTX849, a Covalent KRAS G12C Inhibitor for the Treatment of Cancer. J Med Chem. 2020 Jul 9;63(13):6679-6693. DOI:10.1021/acs.jmedchem.9b02052 |
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