| Hazard Information | Back Directory | [Uses]
STAT3 degrader-2 is a PROTAC-based degrader of STAT3. STAT3 degrader-2 can degrade the level of total STAT3 protein. STAT3 degrader-2 can be used for the research of cancer and other diseases[1]. STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [in vivo]
STAT3 degrader-2 (Compound 92) (i.v.; 50 mg/kg; 6 h, 24 h, 48 h) decreased the level of total STAT3 protein and phosphorylated STAT3 (Y705) protein in acute leukemia Molm-16 tumors and SU-DHL-1 tumors in mice[1].
STAT3 degrader-2 (i.v.; 25, 50 mg/kg; qw) shows antitumor activity against Molm-16 xenograft tumors in mice[1]. | Animal Model: | Mice[1] | | Dosage: | 25, 50 mg/kg | | Administration: | i.v.; qw | | Result: | Showed antitumor activity in Molm-16 and SU-DHL-1 xenograft mice. |
| [References]
[1] Shaomeng Wang, et al. Small molecule degraders of stat3. Patent. WO2020198435A1. |
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