| Identification | Back Directory | [Name]
2,4(1H,3H)-Pyrimidinedione, 6-(cyclohexylthio)-1-(ethoxymethyl)-5-(1-methylethyl)- | [CAS]
251481-69-3 | [Synonyms]
TNK6123
TNK-6123
TNK 6123
2,4(1H,3H)-Pyrimidinedione, 6-(cyclohexylthio)-1-(ethoxymethyl)-5-(1-methylethyl)- | [Molecular Formula]
C16H26N2O3S | [MOL File]
251481-69-3.mol | [Molecular Weight]
326.45 |
| Hazard Information | Back Directory | [Description]
TNK-6123 is an emivirine analog with improved activity against drug-resistant HIV mutants. | [Uses]
TNK-6123 is a potent Emivirine (HY-15353) analogue with improved activity against drug-resistant HIV mutants. TNK-6123 improves activity against Lys103Asn mutant RT[1]. | [Definition]
ChEBI: 6-cyclohexylsulfanyl-1-ethoxymethyl-5-isopropyluracil is a pyrimidone that is uracil in which positions 1, 5, and 6 are substituted by ethoxymethyl, isopropyl, and cyclohexylsulfanyl groups, respectively. It is a pyrimidone and an aliphatic sulfide. It is functionally related to a uracil. | [References]
[1] Hopkins AL, et al. Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. J Med Chem. 1999 Nov 4;42(22):4500-5. DOI:10.1021/jm990192c |
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