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P-gp inhibitor 17 (compound 2g) is a P-gp inhibitor directly interacted with the transmembrane domain of P-gp. P-gp inhibitor 17 can be used for P-gp-mediated multidrug-resistant in tumor cells study[1]. | [References]
[1] Ziqian Wang, et al. Exploiting the “Hot-Spots” of Hsp70–Bim Protein–Protein Interaction to Optimize the 1-Oxo-1H-phenalene-2,3-dicarbonitrile Analogues as Specific Hsp70–Bim Inhibitors. .Med. Chem. 2023, 66, 23, 16377–16387
Publication Date:November 27, 2023 |
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