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2562329-14-8

2562329-14-8 Structure

2562329-14-8 Structure
IdentificationBack Directory
[Name]

Pyrazolo[4'',3'':3',4']cyclohepta[1',2':4,5]thieno[3,2-d]pyrimidin-10(9H)-one, 8-(2R)-1-azabicyclo[2.2.2]oct-2-yl-2,4,5,6-tetrahydro-
[CAS]

2562329-14-8
[Synonyms]

Cdc7-IN-18
Pyrazolo[4'',3'':3',4']cyclohepta[1',2':4,5]thieno[3,2-d]pyrimidin-10(9H)-one, 8-(2R)-1-azabicyclo[2.2.2]oct-2-yl-2,4,5,6-tetrahydro-
[Molecular Formula]

C19H21N5OS
[MOL File]

2562329-14-8.mol
[Molecular Weight]

367.47
Chemical PropertiesBack Directory
[Boiling point ]

662.4±65.0 °C(Predicted)
[density ]

1.76±0.1 g/cm3(Predicted)
[pka]

8.21±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

Cdc7-IN-18 (compound 1-2) is a potent CDC7 inhibitor with an IC50 of 1.29 nM for Cdc7/DBF4 enzyme. Cdc7-IN-18 shows antiproliferative activities with IC50 of 53.62 nM in COLO205 cells[1].
[IC 50]

Cdc7: 1.29 nM (IC50)
[References]

[1] Li Gang, et al. Tetracyclic compounds as cdc7 inhibitors. WO2020239107A1.
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