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2567564-33-2

2567564-33-2 Structure

2567564-33-2 Structure
IdentificationBack Directory
[Name]

5-Oxaspiro[3.4]octane-7,8-diol, 6-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-, (1R,4R,6R,7R,8S)-
[CAS]

2567564-33-2
[Synonyms]

PRMT5-IN-11
5-Oxaspiro[3.4]octane-7,8-diol, 6-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-, (1R,4R,6R,7R,8S)-
[Molecular Formula]

C13H17N5O4
[MOL File]

2567564-33-2.mol
[Molecular Weight]

307.31
Chemical PropertiesBack Directory
[Boiling point ]

691.8±65.0 °C(Predicted)
[density ]

2.00±0.1 g/cm3(Predicted)
[pka]

13.10±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

PRMT5-IN-11 is a promising structure-dependent inhibition of the protein methyltransferase PRMT5:MEP50 complex in the (sub)micromolar range.
[References]

[1] Jouffroy L, et al. Regio- and Stereoselective Synthesis of C-4' Spirocyclobutyl Ribofuranose Scaffolds and Their Use as Biologically Active Nucleoside Analogues. Org Lett. 2021 Nov 19;23(22):8828-8833. DOI:10.1021/acs.orglett.1c03334
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