| Identification | Back Directory | [Name]
Benzenesulfonamide, 2-methoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- | [CAS]
2569008-99-5 | [Synonyms]
KAT6-IN-1
Benzenesulfonamide, 2-methoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- | [Molecular Formula]
C19H18N4O5S | [MOL File]
2569008-99-5.mol | [Molecular Weight]
414.43 |
| Chemical Properties | Back Directory | [Boiling point ]
660.9±65.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
6.84±0.30(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C19H18N4O5S/c1-26-14-6-3-4-7-17(14)29(24,25)22-19-18-15(27-2)10-13(11-16(18)28-21-19)12-23-9-5-8-20-23/h3-11H,12H2,1-2H3,(H,21,22) | [InChIKey]
RCBWSTJGOASLEO-UHFFFAOYSA-N | [SMILES]
C1(S(NC2C3=C(ON=2)C=C(CN2C=CC=N2)C=C3OC)(=O)=O)=CC=CC=C1OC |
| Hazard Information | Back Directory | [Uses]
KAT6-IN-1 (compound E) is a potent inhibitor of histone acetyltransferases KAT6A and KAT6B. KAT6-IN-1 can be used in cancer research[1]. | [in vivo]
KAT6-IN-1 (3 mg/kg, po, QD for 21 days) exhibits antitumor efficacy in mouse ST340 xenograft model[2]. | Animal Model: | Mouse ST340 xenograft model[2] | | Dosage: | 3 mg/kg | | Administration: | po, QD for 21 days | | Result: | Inhibited tumor growth with a TGI of 55.4%. |
| [References]
[1] Paul AS, et, al. Kat6 inhibitor methods and combinations for cancer treatment. WO2022013369.
[2] Stupple PA, et al., Kat6 inhibitor methods and combinations for cancer treatment. WO2022013369. |
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