| Identification | Back Directory | [Name]
3-Pyrrolidinecarboxamide, N-[(3,5-difluorophenyl)methyl]-3-hydroxy-1-(1H-indol-5-yl)-2-oxo-, (3R)- | [CAS]
2575547-29-2 | [Synonyms]
3-Pyrrolidinecarboxamide, N-[(3,5-difluorophenyl)methyl]-3-hydroxy-1-(1H-indol-5-yl)-2-oxo-, (3R)- | [Molecular Formula]
C20H17F2N3O3 | [MOL File]
2575547-29-2.mol | [Molecular Weight]
385.36 |
| Chemical Properties | Back Directory | [Boiling point ]
755.6±60.0 °C(Predicted) | [density ]
1.496±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 140 mg/mL (363.30 mM; Need ultrasonic) | [form ]
Solid | [pka]
11.51±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(R)-M8891 (compound R-9) is a less active isomer of M8891. M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor[1]. | [Biological Activity]
(R)-M8891 (compound R-9) is a less active isomer of M8891. M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor[1]. | [storage]
4°C, protect from light | [References]
[1]. Timo Heinrich, et al. Process for manufacturing (s)-3-hydroxy-1-(1h-indol-5-yl)-2-oxo-pyrrolidine-3-carboxylic acid 3,5-difluoro-benzylamide. WO2021001328A1. |
|
|