| Identification | Back Directory | [Name]
2640677-68-3 | [CAS]
2640677-68-3 | [Synonyms]
PARP1-IN-33
4-(4-(3-(8-fluoro-1-oxo-1,2-dihydroisoquinolin-3-yl)propyl)piperazin-1-yl)benzonitrile hydrochloride
Benzonitrile, 4-[4-[3-(8-fluoro-1,2-dihydro-1-oxo-3-isoquinolinyl)propyl]-1-piperazinyl]-, hydrochloride |
| Hazard Information | Back Directory | [Uses]
PARP1-IN-33 (Example 6) is a PARP1 inhibitor (IC50: 0.41 nM). PARP1-IN-33 has retinal cytoprotective effect, with an EC50 of 0.02 nM (inhibition on MTS activity of H2O2 induced human retinal pigment epithelial cell)[1]. | [IC 50]
PARP1: 0.41 nM (IC50) | [References]
[1] ???, et al. Isoquinolinone derivative, preparation method therefor, and pharmaceutical composition, comprising same as active ingredient, for prevention or treatment of poly(adp-ribose)polymerase-1 (parp-1)-associated disease, WO2021086077, WPO, 2021-05-06. |
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