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2647464-92-2

2647464-92-2 Structure

2647464-92-2 Structure
IdentificationBack Directory
[Name]

Urea, N-(3-fluoro-2-methylphenyl)-N'-(8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)-
[CAS]

2647464-92-2
[Synonyms]

CXCR2 antagonist 3
Urea, N-(3-fluoro-2-methylphenyl)-N'-(8-hydroxy-1,1-dioxido-2H-1-benzothiopyran-7-yl)-
[Molecular Formula]

C17H15FN2O4S
[MOL File]

2647464-92-2.mol
[Molecular Weight]

362.38
Chemical PropertiesBack Directory
[Boiling point ]

474.3±45.0 °C(Predicted)
[density ]

1.538±0.06 g/cm3(Predicted)
[pka]

6.28±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues[1].
[References]

[1] Dong Y, et al. Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. J Med Chem. 2021;64(22):16626-16640. DOI:10.1021/acs.jmedchem.1c01219
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