| Identification | Back Directory | [Name]
1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide | [CAS]
2648418-86-2 | [Synonyms]
DGKα-IN-3
1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide |
| Hazard Information | Back Directory | [Uses]
DGKα-IN-3 (example 25) is a DGKα inhibitor with the IC50 of 283 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study. | [References]
[1] Schmees, Norbert, et al. Preparation of substituted aminoquinolones as DGKα inhibitors for immune activation. WO2021105115. |
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