| Identification | Back Directory | [Name]
2H-Indol-2-one, 3-[(3,5-dichloro-4-hydroxyphenyl)methylene]-5-(2-furanylcarbonyl)-1,3-dihydro- | [CAS]
265098-01-9 | [Synonyms]
GW406108X(Z/E)
GW406108X(Z/E), 10 mM in DMSO
GW406108X(Z/E),GW-406108X(Z/E)
3-(3,5-Dichloro-4-hydroxybenzylidene)-5-(furan-2-carbonyl)indolin-2-one
2H-Indol-2-one, 3-[(3,5-dichloro-4-hydroxyphenyl)methylene]-5-(2-furanylcarbonyl)-1,3-dihydro- | [Molecular Formula]
C20H11Cl2NO4 | [MOL File]
265098-01-9.mol | [Molecular Weight]
400.21 |
| Hazard Information | Back Directory | [Uses]
(Z/E)-GW406108X is a mixture of different configurations of GW406108X (HY-115570). GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM[1]. | [References]
[1] Zachari M, et al. The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets. Biochem J. 2020;477(4):801-814. DOI:10.1042/BCJ20190846
[2] Dumas ME, et al. Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes. Bioorg Med Chem Lett. 2019;29(2):148-154. DOI:10.1016/j.bmcl.2018.12.008 |
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