| Identification | Back Directory | [Name]
5,8,11-Eicosatrienoic-5,6,8,9,11,12-d6 acid, (5Z,8Z,11Z)- | [CAS]
2692624-12-5 | [Synonyms]
5,8,11-Eicosatrienoic-5,6,8,9,11,12-d6 acid, (5Z,8Z,11Z)- | [Molecular Formula]
C20H34O2 | [MOL File]
2692624-12-5.mol | [Molecular Weight]
306.49 |
| Hazard Information | Back Directory | [Description]
5(Z),8(Z),11(Z)-Eicosatrienoic Acid-d6 contains six deuterium atoms at the 5, 6, 8, 9, 11, and 12 positions. It is intended for use as an internal standard for the quantification of 5(Z),8(Z),11(Z)-eicosatrienoic acid by GC- or LC-mass spectrometry. Eicosatrienoic acid accumulates in the tissues of animals fed diets deficient in both ω-3 and ω-6 fatty acids. It can be converted to 3-series cysteinyl-leukotrienes but cannot serve as a COX substrate.1 The kidneys from essential fatty acid deficient rats are less immunogenic when transplanted, and the metabolites of eicosatrienoic acid are believed to play a role in altering the immune status of these organs.2 | [Uses]
Mead acid-d6 is the deuterium labeled Mead acid. Mead acid (5,8,11-Eicosatrienoic acid), an unsaturated (Omega-9) fatty acid, is an indicator of essential fatty acid deficiency[1]. | [References]
1. Lefkowith, J.B. Essential fatty acid deficiency: Probing the role of arachidonate in biology Adv. Prostaglandin Thromboxane Leukot. Res. 20,224-231(1990).
2. Schreiner, G.F., Flye, W., Brunt, E., et al. Essential fatty acid depletion of renal allografts and prevention of rejection Science 240,1032-1033(1988). |
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