| Hazard Information | Back Directory | [Uses]
STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1]. | [in vivo]
STING agonist-31 (Compound 40) (10 mg/kg, i.v.) inhibits tumor growth in 4T1 and CT26 tumor mice model[1].
STING agonist-31 (1 mg/kg, i.v., rats) shows T1/2: 0.697 h, AUClast: 678 h?ng/mL[1].
| Animal Model: | Mice models bearing orthotopic transplanted breast tumor (4T1) or subcutaneous transplanted colon tumor (CT26)[1] | | Dosage: | 10 mg/kg | | Administration: | i.v., at days 1, 4, and 7 | | Result: | Inhibited tumor Growth. |
| [References]
[1] Song Z, et al. Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists. J Med Chem. 2021 Feb 11;64(3):1649-1669. DOI:10.1021/acs.jmedchem.0c01900 |
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