ChemicalBook--->CAS DataBase List--->272105-42-7

272105-42-7

        272105-42-7 Structure

        272105-42-7 Structure
        IdentificationBack Directory
        [Name]

        Disitertide
        [CAS]

        272105-42-7
        [Synonyms]

        disitertide
        P144 Peptide
        TSLDASIIWAMMQN
        DISITERTIDE, >98%
        P144;P144 PEPTIDE
        Disitertide,P144,P144 Peptide, >98%
        L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-
        L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine
        [Molecular Formula]

        C68H109N17O22S2
        [MOL File]

        272105-42-7.mol
        [Molecular Weight]

        1580.84
        Chemical PropertiesBack Directory
        [Boiling point ]

        1968.7±65.0 °C(Predicted)
        [density ]

        1.327
        [storage temp. ]

        Store at -20°C
        [solubility ]

        DMSO : ≥ 200 mg/mL (126.52 mM);Water : < 0.1 mg/mL (insoluble)
        [form ]

        Solid
        [pka]

        3.15±0.10(Predicted)
        [color ]

        White to off-white
        [InChI]

        InChI=1/C68H109N17O22S2/c1-12-32(5)53(85-67(105)54(33(6)13-2)84-64(102)48(30-87)82-56(94)35(8)74-61(99)45(27-51(91)92)79-62(100)43(24-31(3)4)78-63(101)47(29-86)83-65(103)52(71)36(9)88)66(104)80-44(25-37-28-72-39-17-15-14-16-38(37)39)60(98)73-34(7)55(93)75-41(20-22-108-10)58(96)77-42(21-23-109-11)59(97)76-40(18-19-49(69)89)57(95)81-46(68(106)107)26-50(70)90/h14-17,28,31-36,40-48,52-54,72,86-88H,12-13,18-27,29-30,71H2,1-11H3,(H2,69,89)(H2,70,90)(H,73,98)(H,74,99)(H,75,93)(H,76,97)(H,77,96)(H,78,101)(H,79,100)(H,80,104)(H,81,95)(H,82,94)(H,83,103)(H,84,102)(H,85,105)(H,91,92)(H,106,107)/t32-,33-,34-,35-,36+,40-,41-,42-,43-,44-,45-,46-,47-,48-,52-,53-,54-/s3
        [InChIKey]

        IUYPEUHIWDMJLM-INGCBPSVNA-N
        [SMILES]

        C(C1=CNC2=CC=CC=C12)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@H](C(=O)O)CC(=O)N)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@H](O)C |&1:10,14,19,27,35,44,55,56,63,64,71,77,82,90,98,104,106,r|
        Hazard InformationBack Directory
        [Description]

        Disitertide is an inhibitor of TGF-β1. It prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter. Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4.
        [Biological Activity]

        Disitertide (P144) TFA is a polypeptide inhibitor of transforming growth factor TGFβ1, specifically blocking its interaction with the receptor. Disitertide (P144) is also an inhibitor of PI3K and an inducer of apoptosis.
        [in vitro]

        Disitertide (100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells.
        Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance.
        Disitertide (P144, 10 μg/mL to 200 μg/mL) affects proliferation,

        Western Blot Analysis

        < td class="col2"> Significantly suppressed the protein expression levels of PI3K and p-Akt, and induced the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group. table>
        Cell Line: Mouse embryo osteoblast precursor MC3T3-E1 cells.
        Concentration:
        Concentration: 100 μg/mL.
        Incubation Time: 4 h.
        Result:
        [in vivo]

        Disitertide (Topical application, 300 μg/mL) may promote scar maturation and clinical improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment.

        Animal Model: Human hypertrophic scars were implanted in 60 nude mice.
        Dosage: 300 μg/mL was added the Lipogel.
        Administration: Topical application daily administered.
        Result: Successful shedding was achieved in 83,3% of the xenografts.
        [storage]

        Store at -20°C
        272105-42-7 suppliers list
        Company Name: Shenzhen Nexconn Pharmatechs Ltd
        Tel: +86-755-89396905 +86-15013857715 , +86-15013857715
        Website: www.hezefdc.com/ShowSupplierProductsList31188/0_EN.htm
        Company Name: CONIER CHEM AND PHARMA LIMITED
        Tel: +8618523575427 , +8618523575427
        Website: http://www.conier.com/
        Company Name: TargetMol Chemicals Inc.
        Tel: +1-781-999-5354; +17819995354 , +17819995354
        Website: https://www.targetmol.com/
        Company Name: Career Henan Chemica Co
        Tel: +86-0371-86658258 +8613203830695 , +8613203830695
        Website: www.coreychem.com/
        Company Name: BOC Sciences
        Tel: 16314854226; +16314854226 , +16314854226
        Website: https://www.bocsci.com/
        Company Name: Zhejiang J&C Biological Technology Co.,Limited
        Tel: +1-2135480471 +1-2135480471; , +1-2135480471;
        Website: https://www.sarms4muscle.com
        Company Name: TargetMol Chemicals Inc.
        Tel: +1-781-999-5354;
        Website: https://www.targetmol.com/
        Company Name: GIHI CHEMICALS CO.,LIMITED
        Tel: +86-571-86217390; +8618058761490 , +8618058761490
        Website: https://www.gihichem.com/
        Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
        Tel: +86-18621343501; +undefined18621343501 , +undefined18621343501
        Website: http://www.acmec.com.cn/
        Company Name: SHANGHAI KEAN TECHNOLOGY CO., LTD.
        Tel: +8613817748580 , +8613817748580
        Website: www.kean-chem.com
        Company Name: Changsha MOL Changes Biotechnology Co., Ltd.
        Tel: +8619375158599 , +8619375158599
        Website: www.molchanges.com
        Company Name: LEON (NANJING) BIOTECHNOLOGY CO., LTD.
        Tel: +8615051830413 , +8615051830413
        Website: www.njleonbiotech.com
        Company Name: DONBOO AMINO ACID COMPANY
        Tel: +8618051385538 , +8618051385538
        Website: www.donboo.com/
        Company Name: MedChemexpress LLC  
        Tel: 021-58955995
        Website: www.medchemexpress.cn
        Company Name: Wuxi Zhongkun Biochemical Technology Co., Ltd.  
        Tel: 0510-85629785 18013409632
        Website: www.reading-chemicals.com
        Company Name: ShangHai Biochempartner Co.,Ltd  
        Tel: 177-54423994 17754423994
        Website: https://www.biochempartner.com
        Company Name: Beijing Solarbio Science & Tecnology Co., Ltd.  
        Tel: 010-50973130 18101056239
        Website: www.solarbio.com
        Company Name: Nanjing Leon Biological Technology Co., Ltd.  
        Tel: 025-84523390 -127; 17705183659
        Website: http://www.njleonbiotech.com
        Tags:272105-42-7 Related Product Information
        39537-23-0 56-53-1 70-47-3 56-85-9

        • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
        • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
          According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
        • Copyright © 2023 ChemicalBook All rights reserved.
        浦东新区| 长春市| 通州区| 隆子县| 砚山县| 买车| 北京市| 邹城市| 山阳县| 宜川县| 理塘县| 淮阳县| 石城县| 宁城县| 涞水县| 荔波县| 岳阳市| 阿城市| 离岛区| 通河县| 平塘县| 无为县| 崇文区| 获嘉县| 和田市| 独山县| 固阳县| 宁德市| 鹤庆县| 双鸭山市| 芒康县| 法库县| 汤阴县| 清原| 象山县| 信宜市| 白沙| 辽阳市| 郓城县| 安国市| 高雄市|