| Chemical Properties | Back Directory | [Boiling point ]
1784.8±65.0 °C(predicted) | [density ]
1.35±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
9.89±0.15(predicted) | [Sequence]
Ac-Cys-Pro-Pro-Tyr-Leu-Pro-cyclo(Lys-Tyr-Leu-Cys-Asp)-Leu-Ile-NH2 (disulfide bridge:Cys1-Cys10) |
| Hazard Information | Back Directory | [Uses]
KS-133 is a selective and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2), with the IC50 values of 24.8 nM and 500 nM in Ca influx assay and cAMP assay. KS-133 plays an important role in schizophrenia research[1]. | [References]
[1] Kotaro Sakamoto, et al. Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders. Front Pharmacol. 2021 Nov 4:12:751587. DOI:10.3389/fphar.2021.751587 |
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