| Identification | Back Directory | [Name]
2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, hydrochloride (1:1), (2E)- | [CAS]
2727965-45-7 | [Synonyms]
2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, hydrochloride (1:1), (2E)- | [Molecular Formula]
C24H30ClN3O2 | [MOL File]
2727965-45-7.mol | [Molecular Weight]
427.97 |
| Hazard Information | Back Directory | [Biological Activity]
FK 866 hydrochloride is a non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by etoposide and cisplatin . | [storage]
Store at -20°C |
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